Like transistors in a computer, synapses perform complex computations and connect the brain's non-linear processing elements (neurons) into a functional circuit. Understanding the role of synapses in neuronal computation is essential to understanding how the brain works. In this course students will be introduced to cutting-edge research in the field of synaptic neurophysiology. The course will cover such topics as synapse formation, synaptic function, synaptic plasticity, the roles of synapses in higher cognitive processes and how synaptic dysfunction can lead to disease. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.

The objective of this course is to introduce large-scale atomistic modeling techniques and highlight its importance for solving problems in modern engineering sciences. We demonstrate how atomistic modeling can be used to understand how materials fail under extreme loading, involving unfolding of proteins and propagation of cracks.

Explores the impact of the printing press upon European politics and culture during the first several centuries after Gutenberg and compares these changes with the possibilities and problems inherent in contemporary electronic technologies of the word. Assignments include formal essays and online projects. There has been much discussion in recent years, on this campus and elsewhere, about the death of the book. Digitization and various forms of electronic media, some critics say, are rendering the printed text as obsolete as the writing quill. In this subject, we will examine the claims for and against the demise of the book, but we will also supplement these arguments with an historical perspective they lack: we will examine texts, printing technologies, and reading communities from roughly 1450 to the present. We will begin with the theoretical and historical overviews of Walter Ong and Elizabeth Eisenstein, after which we will study specific cases such as English chapbooks, Inkan knotted and dyed strings, late nineteenth-century recording devices, and newspapers online today. We will also visit a rare book library and make a poster on a hand-set printing press.

Examines interactions across the Eurasian continent between Russians, Chinese, Mongolian nomads, and Turkic oasis dwellers during the last millennium and a half. As empires rose and fell, religions, trade, and war flowed back and forth continuously across this vast space. Britain and Russia competed for power over Eurasia in the "Great Game" of geopolitics in the nineteenth century, just as China, Russia, and others did in the twentieth century. Today, the fall of the Soviet Union and China's reforms have opened new opportunities for cultural interaction. Topics include: the religious traditions of Central Asian Islam, Buddhism, Christianity, and Confucianism; caravans and travelers like Marco Polo and Rabban Sauma, the first Chinese to travel to the West; and nomadic conquest and imperialist competition, past and present. Source materials include primary documents, travelogues, films, music, and museum visits.

The need to identify sustainable forms of energy as an alternative to our dependence on depleting worldwide oil reserves is one of the grand challenges of our time. The energy from the sun converted into plant biomass is the most promising renewable resource available to humanity. This seminar will examine each of the critical steps along the pathway towards the conversion of plant biomass into ethanol. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.

We are now at an unprecedented point in the field of neuroscience: We can watch the human brain in action as it sees, thinks, decides, reads, and remembers. Functional magnetic resonance imaging (fMRI) is the only method that enables us to monitor local neural activity in the normal human brain in a noninvasive fashion and with good spatial resolution. A large number of far-reaching and fundamental questions about the human mind and brain can now be answered using straightforward applications of this technology. This is particularly true in the area of high-level vision, the study of how we interpret and use visual information including object recognition, mental imagery, visual attention, perceptual awareness, visually guided action, and visual memory. The goals of this course are to help students become savvy and critical readers of the current neuroimaging literature, to understand the strengths and weaknesses of the technique, and to design their own cutting-edge, theoretically motivated studies. Students will read, present to the class, and critique recently published neuroimaging articles, as well as write detailed proposals for experiments of their own. Lectures will cover the theoretical background on some of the major areas in high-level vision, as well as an overview of what fMRI has taught us and can in future teach us about each of these topics. Lectures and discussions will also cover fMRI methods and experimental design. A prior course in statistics and at least one course in perception or cognition are required.

This team-taught multidisciplinary course provides information relevant to the conduct and interpretation of human brain mapping studies. It begins with in-depth coverage of the physics of image formation, mechanisms of image contrast, and the physiological basis for image signals. Parenchymal and cerebrovascular neuroanatomy and application of sophisticated structural analysis algorithms for segmentation and registration of functional data are discussed. Additional topics include: fMRI experimental design including block design, event related and exploratory data analysis methods, and building and applying statistical models for fMRI data; and human subject issues including informed consent, institutional review board requirements and safety in the high field environment. Additional Faculty Div Bolar Dr. Bradford Dickerson Dr. John Gabrieli Dr. Doug Greve Dr. Karl Helmer Dr. Dara Manoach Dr. Jason Mitchell Dr. Christopher Moore Dr. Vitaly Napadow Dr. Jon Polimeni Dr. Sonia Pujol Dr. Bruce Rosen Dr. Mert Sabuncu Dr. David Salat Dr. Robert Savoy Dr. David Somers Dr. A. Gregory Sorensen Dr. Christina Triantafyllou Dr. Wim Vanduffel Dr. Mark Vangel Dr. Lawrence Wald Dr. Susan Whitfield-Gabrieli Dr. Anastasia Yendiki

The basic properties of functions of one complex variable. Cauchy's theorem, holomorphic and meromorphic functions, residues, contour integrals, conformal mapping. Infinite series and products, the gamma function, the Mittag-Leffler theorem. Harmonic functions, Dirichlet's problem. This is an advanced undergraduate course dealing with calculus in one complex variable with geometric emphasis. Since the course Analysis I is a prerequisite, topological notions like compactness, connectedness, and related properties of continuous functions are taken for granted. This course offers biweekly problem sets with solutions, two term tests and a final exam, all with solutions.

Fundamentals of Biology focuses on the basic principles of biochemistry, molecular biology, genetics, and recombinant DNA. These principles are necessary to understanding the basic mechanisms of life and anchor the biological knowledge that is required to understand many of the challenges in everyday life, from human health and disease to loss of biodiversity and environmental quality.

This class covers the history of 20th century art and design from the perspective of the technologist. Methods for visual analysis, oral critique, and digital expression are introduced. Class projects this term use the OLPC XO (One Laptop Per Child) laptop, Csound and Python software.

This design-based subject provides a first course in energy and thermo-sciences with applications to sustainable energy-efficient architecture and building technology. No previous experience with subject matter is assumed. After taking this subject, students will understand introductory thermodynamics and heat transfer, know the leading order factors in building energy use, and have creatively employed their understanding of energy fundamentals and knowledge of building energy use in innovative building design projects. This year, the focus will be on design projects that will complement the new NSTAR/MIT campus efficiency program.

Introduces students to the basics of musical structure and proficiencies expected of musicians through participation in three integrated hands-on approaches. Lectures introduce students to the basics of music--pitch, rhythm, and its combinations--in a variety of musical settings, including analysis and discussion of students' compositions and of related larger works. Sight-singing lab focuses on developing practical musical skills through oral, aural, and written experiences with rhythms, melodies, intervals, scales, chords, and music notation. Piano lab introduces and continues development of fundamental music skills through keyboard practice.

Fundamentals of photoelectric conversion: charge excitation, conduction, separation, and collection. Lectures cover commercial and emerging photovoltaic technologies and cross-cutting themes, including conversion efficiencies, loss mechanisms, characterization, manufacturing, systems, reliability, life-cycle analysis, risk analysis, and technology evolution in the context of markets, policies, society, and environment.

This course is one of many OCW Energy Courses, and it is an elective subject in MIT's undergraduate Energy Studies Minor. This Institute–wide program complements the deep expertise obtained in any major with a broad understanding of the interlinked realms of science, technology, and social sciences as they relate to energy and associated environmental challenges.

General introduction to systems engineering using both the classical V-model and the new Meta approach. Topics include stakeholder analysis, requirements definition, system architecture and concept generation, trade-space exploration and concept selection, design definition and optimization, system integration and interface management, system safety, verification and validation, and commissioning and operations. Discusses the trade-offs between performance, lifecycle cost and system operability. Readings based on systems engineering standards and papers. Students apply the concepts of systems engineering to a cyber-electro-mechanical system, which is subsequently entered into a design competition.

Furniture making is in many ways like bridge building, connections holding posts apart with spans to support a deck. Many architects have tried their hand at furniture design, Wright, Mies Van Der Rohe, Aalto, Saarinen, Le Corbusier, and Gerhy. We will review the history of furniture making in America with a visit to the Decorative Arts Collection at the Museum of Fine Arts in Boston and have Cambridge artist/craftsman Mitch Ryerson show us his work and talk about design process. Students will learn traditional woodworking techniques beginning with the use of hand tools, power tools and finally woodworking machines. Students will build a single piece of furniture of an original design that must support someone weighing 185 lbs. sitting on it 12 inches off the ground made primarily of wood. Students should expect to spend approximately 80 hours in the shop outside of class time. Preregistered architecture students will get first priority but first meeting attendance is mandatory. Twelve student maximum, no exceptions.

This is a freshman advising seminar. The professor of a FAS is the first year advisor to the (no more than 8) students in the seminar. The use of Global Positioning System (GPS) in a wide variety of applications has exploded in the last few years. In this seminar we explore how positions on the Earth were determined before GPS; how GPS itself works and the range of applications in which GPS is now a critical element. This seminar is followed by a UROP research project in the spring semester where results from precise GPS measurements will be analyzed and displayed on the Web.

This course provides practical instruction in the design and analysis of non-digital games. Students cover the texts, tools, references and historical context to analyze and compare game designs across a variety of genres, including sports, game shows, games of chance, card games, schoolyard games, board games, and role–playing games. In teams, students design, develop, and thoroughly test their original games to understand the interaction and evolution of game rules. Students taking the graduate version complete additional assignments.

An historical examination and analysis of the evolution and development of games and game mechanics. Topics include a large breadth of genres and types of games, including sports, game shows, games of chance, schoolyard games, board games, roleplaying games, and digital games. Students submit essays documenting research and analysis of a variety of traditional and eclectic games. Project teams required to design, develop, and thoroughly test their original games.

This half-term course examines the choices that we make which affect others and the choices others make that affect us. Such situations are known as "games" and game-playing, while sounding whimsical, is serious business. Managers frequently play games both within the firm and outside it - with competitors, customers, regulators, and even capital markets! The goal of this course is to enhance your ability to think strategically in complex, interactive environments. Knowledge of game theory will give you an advantage in such strategic settings. The course is structured around three "themes for acquiring advantage in games": commitment / strategic moves, exploiting hidden information, and limited rationality.

The studio will focus on the district of Gaoming, located in the northwest of the Pearl River Delta (PRD) - the fastest growing and most productive region of China. The District has recently completed a planning effort in which several design institutes and a Hong Kong planning firm prepared ideas for a new central area near the river. The class will complement these efforts by focusing on planning and design options on the waterfront of the proposed new district and ways of integrating water/hydrological factors into all aspects and land uses of a modern city (residential, commercial, industrial) - including watershed and natural ecosystem protection, economic and recreational activities, transportation, and tourism.