This course is an introduction to computational biology emphasizing the fundamentals of …
This course is an introduction to computational biology emphasizing the fundamentals of nucleic acid and protein sequence and structural analysis; it also includes an introduction to the analysis of complex biological systems. Topics covered in the course include principles and methods used for sequence alignment, motif finding, structural modeling, structure prediction and network modeling, as well as currently emerging research areas.
During development, the genetic content of each cell remains, with a few …
During development, the genetic content of each cell remains, with a few exceptions, identical to that of the zygote. Most differentiated cells therefore retain all of the genetic information necessary to generate an entire organism. It was through pioneering technology of somatic cell nuclear transfer (SCNT) that this concept was experimentally proven. Only 10 years ago the sheep Dolly was the first mammal to be cloned from an adult organism, demonstrating that the differentiated state of a mammalian cell can be fully reversible to a pluripotent embryonic state. A key conclusion from these experiments was that the difference between pluripotent cells such as embryonic stem (ES) cells and unipotent differentiated cells is solely a consequence of reversible changes. These changes, which have proved to involve reversible alterations to both DNA and to proteins that bind DNA, are known as epigenetic, to distinguish them from genetic alterations to DNA sequence. In this course we will explore such epigenetic changes and study different approaches that can return a differentiated cell to an embryonic state in a process referred to as epigenetic reprogramming, which will ultimately allow generation of patient-specific stem cells and application to regenerative therapy. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.
Linear elastic and elastic-plastic fracture mechanics. Experimental methods. Microstructural effects on fracture …
Linear elastic and elastic-plastic fracture mechanics. Experimental methods. Microstructural effects on fracture in metals, ceramics, polymers, thin films, biological materials and composites. Toughening mechanisms. Crack growth resistance and creep fracture. Interface fracture mechanics. Fatigue damage and dislocation substructures in single crystals. Stress- and strain-life approach to fatigue. Fatigue crack growth models and mechanisms. Variable amplitude fatigue. Corrosion fatigue. Case studies of fracture and fatigue in structural, bioimplant, and microelectronic components.
Since the discovery of the structure of the DNA double helix in …
Since the discovery of the structure of the DNA double helix in 1953 by Watson and Crick, the information on detailed molecular structures of DNA and RNA, namely, the foundation of genetic material, has expanded rapidly. This discovery is the beginning of the "Big Bang" of molecular biology and biotechnology. In this seminar, students discuss, from a historical perspective and current developments, the importance of pursuing the detailed structural basis of genetic materials.
Are you interested in investigating how nature engineers itself? How engineers copy …
Are you interested in investigating how nature engineers itself? How engineers copy the shapes found in nature ("biomimetics")? This Freshman Seminar investigates why similar shapes occur in so many natural things and how physics changes the shape of nature. Why are things in nature shaped the way they are? How do birds fly? Why do bird nests look the way they do? How do woodpeckers peck? Why can't trees grow taller than they are? Why is grass skinny and hollow? What is the wood science behind musical instruments? Questions such as these are the subject of biomimetic research and they have been the focus of investigation in this course for the past three years.
Like transistors in a computer, synapses perform complex computations and connect the …
Like transistors in a computer, synapses perform complex computations and connect the brain's non-linear processing elements (neurons) into a functional circuit. Understanding the role of synapses in neuronal computation is essential to understanding how the brain works. In this course students will be introduced to cutting-edge research in the field of synaptic neurophysiology. The course will cover such topics as synapse formation, synaptic function, synaptic plasticity, the roles of synapses in higher cognitive processes and how synaptic dysfunction can lead to disease. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.
Students will be able to design and defend a salmon rearing tank …
Students will be able to design and defend a salmon rearing tank for the highest survival rate. They will measure temperature, ph and ammonia on daily basis and make needed adjustments. Given unit ending data students will be able to determine the optimal design for a salmon rearing tank using patterns between water conditions and survival rates.
The need to identify sustainable forms of energy as an alternative to …
The need to identify sustainable forms of energy as an alternative to our dependence on depleting worldwide oil reserves is one of the grand challenges of our time. The energy from the sun converted into plant biomass is the most promising renewable resource available to humanity. This seminar will examine each of the critical steps along the pathway towards the conversion of plant biomass into ethanol. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.
We are now at an unprecedented point in the field of neuroscience: …
We are now at an unprecedented point in the field of neuroscience: We can watch the human brain in action as it sees, thinks, decides, reads, and remembers. Functional magnetic resonance imaging (fMRI) is the only method that enables us to monitor local neural activity in the normal human brain in a noninvasive fashion and with good spatial resolution. A large number of far-reaching and fundamental questions about the human mind and brain can now be answered using straightforward applications of this technology. This is particularly true in the area of high-level vision, the study of how we interpret and use visual information including object recognition, mental imagery, visual attention, perceptual awareness, visually guided action, and visual memory. The goals of this course are to help students become savvy and critical readers of the current neuroimaging literature, to understand the strengths and weaknesses of the technique, and to design their own cutting-edge, theoretically motivated studies. Students will read, present to the class, and critique recently published neuroimaging articles, as well as write detailed proposals for experiments of their own. Lectures will cover the theoretical background on some of the major areas in high-level vision, as well as an overview of what fMRI has taught us and can in future teach us about each of these topics. Lectures and discussions will also cover fMRI methods and experimental design. A prior course in statistics and at least one course in perception or cognition are required.
This team-taught multidisciplinary course provides information relevant to the conduct and interpretation …
This team-taught multidisciplinary course provides information relevant to the conduct and interpretation of human brain mapping studies. It begins with in-depth coverage of the physics of image formation, mechanisms of image contrast, and the physiological basis for image signals. Parenchymal and cerebrovascular neuroanatomy and application of sophisticated structural analysis algorithms for segmentation and registration of functional data are discussed. Additional topics include: fMRI experimental design including block design, event related and exploratory data analysis methods, and building and applying statistical models for fMRI data; and human subject issues including informed consent, institutional review board requirements and safety in the high field environment. Additional Faculty Div Bolar Dr. Bradford Dickerson Dr. John Gabrieli Dr. Doug Greve Dr. Karl Helmer Dr. Dara Manoach Dr. Jason Mitchell Dr. Christopher Moore Dr. Vitaly Napadow Dr. Jon Polimeni Dr. Sonia Pujol Dr. Bruce Rosen Dr. Mert Sabuncu Dr. David Salat Dr. Robert Savoy Dr. David Somers Dr. A. Gregory Sorensen Dr. Christina Triantafyllou Dr. Wim Vanduffel Dr. Mark Vangel Dr. Lawrence Wald Dr. Susan Whitfield-Gabrieli Dr. Anastasia Yendiki
Fundamentals of Biology focuses on the basic principles of biochemistry, molecular biology, …
Fundamentals of Biology focuses on the basic principles of biochemistry, molecular biology, genetics, and recombinant DNA. These principles are necessary to understanding the basic mechanisms of life and anchor the biological knowledge that is required to understand many of the challenges in everyday life, from human health and disease to loss of biodiversity and environmental quality.
This design-based subject provides a first course in energy and thermo-sciences with …
This design-based subject provides a first course in energy and thermo-sciences with applications to sustainable energy-efficient architecture and building technology. No previous experience with subject matter is assumed. After taking this subject, students will understand introductory thermodynamics and heat transfer, know the leading order factors in building energy use, and have creatively employed their understanding of energy fundamentals and knowledge of building energy use in innovative building design projects. This year, the focus will be on design projects that will complement the new NSTAR/MIT campus efficiency program.
An online learning resource that covers core science concepts such as states …
An online learning resource that covers core science concepts such as states of matter, examination of mass, velocity and kinetic energy and more. The goal of Hockey Scholar is to build students’ understanding of foundational STEM concepts and develop scientific and critical thinking through the fast paced, exciting game of hockey
During a scavenger hunt and an art project, students learn how to …
During a scavenger hunt and an art project, students learn how to use a handheld GPS receiver for personal navigation. Teachers can request assistance from the Institute of Navigation to find nearby members with experience in using GPS and in locating receivers to use.
The studio will focus on the district of Gaoming, located in the …
The studio will focus on the district of Gaoming, located in the northwest of the Pearl River Delta (PRD) - the fastest growing and most productive region of China. The District has recently completed a planning effort in which several design institutes and a Hong Kong planning firm prepared ideas for a new central area near the river. The class will complement these efforts by focusing on planning and design options on the waterfront of the proposed new district and ways of integrating water/hydrological factors into all aspects and land uses of a modern city (residential, commercial, industrial) - including watershed and natural ecosystem protection, economic and recreational activities, transportation, and tourism.
Presents the anatomy, physiology, biochemistry, biophysics, and bioengineering of the gastrointestinal tract …
Presents the anatomy, physiology, biochemistry, biophysics, and bioengineering of the gastrointestinal tract and associated pancreatic, liver, and biliary systems. Emphasis on the molecular and pathophysiological basis of disease where known. Covers gross and microscopic pathology and clinical aspects. Formal lectures given by core faculty, with some guest lectures by local experts. Selected seminars conducted by students with supervision of faculty. Permission of instructor required. (Only HST students may register under HST.120, graded P/D/F.) The most recent knowledge of the anatomy, physiology, biochemistry, biophysics, and bioengineering of the gastrointestinal tract and the associated pancreatic, liver and biliary tract systems is presented and discussed. Gross and microscopic pathology and the clinical aspects of important gastroenterological diseases are then presented, with emphasis on integrating the molecular, cellular and pathophysiological aspects of the disease processes to their related symptoms and signs.
Express yourself through your genes! See if you can generate and collect …
Express yourself through your genes! See if you can generate and collect three types of protein, then move on to explore the factors that affect protein synthesis in a cell.
Build a gene network! The lac operon is a set of genes …
Build a gene network! The lac operon is a set of genes which are responsible for the metabolism of lactose in some bacterial cells. Explore the effects of mutations within the lac operon by adding or removing genes from the DNA.
Build a gene network! The lac operon is a set of genes …
Build a gene network! The lac operon is a set of genes which are responsible for the metabolism of lactose in some bacterial cells. Explore the effects of mutations within the lac operon by adding or removing genes from the DNA.
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