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Introductory Biology, Spring 2013
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The MIT Biology Department core courses, 7.012, 7.013, and 7.014, all cover the same core material, which includes the fundamental principles of biochemistry, genetics, molecular biology, and cell biology. 7.013 focuses on the application of the fundamental principles toward an understanding of human biology. Topics include genetics, cell biology, molecular biology, disease (infectious agents, inherited diseases and cancer), developmental biology, neurobiology and evolution.Biological function at the molecular level is particularly emphasized in all courses and covers the structure and regulation of genes, as well as, the structure and synthesis of proteins, how these molecules are integrated into cells, and how these cells are integrated into multicellular systems and organisms. In addition, each version of the subject has its own distinctive material.  

Subject:
Biology
Education
Genetics
Life Science
Material Type:
Assessment
Diagram/Illustration
Full Course
Homework/Assignment
Lesson Plan
Reading
Syllabus
Provider:
M.I.T.
Provider Set:
M.I.T. OpenCourseWare
Author:
Diviya Sinha
Hazel Sive
Tyler Jacks
Date Added:
01/01/2013
The King of Dinosaurs or a Chicken Dinner? One Paleontologist’s Quest to Activate Atavistic Genes and Create a Dinosaur
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This lesson uses the fundamentals of protein synthesis as a context for investigating the closest living relative to Tyrannosaurus rex and evaluating whether or not paleontologist and dinosaur expert, Jack Horner, will be able to "create" live dinosaurs in the lab. The first objective is for students to be able to access and properly utilize the NIH's protein sequence database to perform a BLAST, using biochemical evidence to determine T rex's closest living relative. The second objective is for students to be able to explain and evaluate Jack Horner's plans for creating live dinosaurs in the lab. The main prerequisite for the lesson is a basic understanding of protein synthesis, or the flow of information in the cell from DNA to RNA during transcription and then from RNA to protein during translation

Subject:
Genetics
Life Science
Material Type:
Lecture
Provider:
MIT
Provider Set:
MIT Blossoms
Author:
Justin Lessek and Diana Aljets
Date Added:
07/02/2021
Let's Make Silly Putty
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Educational Use
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Students make two different formulations of imitation Silly Putty with varying degrees of cross-linking. They witness how changes in the degree of cross-linking influence the putty properties.

Subject:
Applied Science
Engineering
Genetics
Life Science
Material Type:
Activity/Lab
Provider:
TeachEngineering
Provider Set:
TeachEngineering
Author:
Cherelle M. Bishop
Jeramy Jasmann
Kate McDonnell
Melissa M. Reynolds
Michael A. de Miranda
Date Added:
09/18/2014
Mice Rule! (Or Not)
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Educational Use
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Students explore the relationships between genetics, biodiversity, and evolution through a simple activity involving hypothetical wild mouse populations. First, students toss coins to determine what traits a set of mouse parents possesses, such as fur color, body size, heat tolerance, and running speed. Next they use coin tossing to determine the traits a mouse pup born to these parents possesses. These physical features are then compared to features that would be most adaptive in several different environmental conditions. Finally, students consider what would happen to the mouse offspring if those environmental conditions were to change: which mice would be most likely to survive and produce the next generation?

Subject:
Applied Science
Engineering
Genetics
Life Science
Material Type:
Activity/Lab
Lesson Plan
Provider:
TeachEngineering
Provider Set:
TeachEngineering
Author:
Mary R. Hebrank
Date Added:
09/18/2014
Modi-FLIED
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Students will breed fruit flies through several generations and record their data using mathematical models in order to demonstrate the inheritance of trait variations.

Subject:
Algebra
Genetics
Life Science
Mathematics
Measurement and Data
Numbers and Operations
Ratios and Proportions
Material Type:
Unit of Study
Provider:
Lane County STEM Hub
Provider Set:
Content in Context SuperLessons
Author:
Courtney Stitt
Jessica Johnson
Date Added:
07/07/2021
Molecular Motors
Unrestricted Use
CC BY
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Discover what controls how fast tiny molecular motors in our body pull through a single strand of DNA. How hard can the motor pull in a tug of war with the optical tweezers? Discover what helps it pull harder. Do all molecular motors behave the same?

Subject:
Genetics
Life Science
Material Type:
Simulation
Provider:
University of Colorado Boulder
Provider Set:
PhET Interactive Simulations
Author:
Chris Malley
Kathy Perkins
Meredith Betterton
Mike Dubson
Tom Perkins
Wendy Adams
Date Added:
12/01/2007
Molecular Motors (AR)
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CC BY
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Discover what controls how fast tiny molecular motors in our body pull through a single strand of DNA. How hard can the motor pull in a tug of war with the optical tweezers? Discover what helps it pull harder. Do all molecular motors behave the same?

Subject:
Genetics
Life Science
Material Type:
Simulation
Provider:
University of Colorado Boulder
Provider Set:
PhET Interactive Simulations
Author:
Chris Malley
Kathy Perkins
Meredith Betterton
Michael Dubson
Thomas Perkins
Wendy Adams
Date Added:
12/01/2007
Molecular Structure of Biological Materials (BE.442), Fall 2005
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CC BY-NC-SA
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Basic molecular structural principles of biological materials. Molecular structures of various materials of biological origin, including collagen, silk, bone, protein adhesives, GFP, self-assembling peptides. Molecular design of new biological materials for nanotechnology, biocomputing and regenerative medicine. Graduate students are expected to complete additional coursework. This course, intended for both graduate and upper level undergraduate students, will focus on understanding of the basic molecular structural principles of biological materials. It will address the molecular structures of various materials of biological origin, such as several types of collagen, silk, spider silk, wool, hair, bones, shells, protein adhesives, GFP, and self-assembling peptides. It will also address molecular design of new biological materials applying the molecular structural principles. The long-term goal of this course is to teach molecular design of new biological materials for a broad range of applications. A brief history of biological materials and its future perspective as well as its impact to the society will also be discussed. Several experts will be invited to give guest lectures.

Subject:
Biology
Genetics
Life Science
Material Type:
Full Course
Provider:
M.I.T.
Provider Set:
M.I.T. OpenCourseWare
Author:
Zhang, Shuguang
Date Added:
01/01/2005
Nanomechanics of Materials and Biomaterials, Spring 2007
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CC BY-NC-SA
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This course focuses on the latest scientific developments and discoveries in the field of nanomechanics, the study of forces and motion on extremely tiny (10-9 m) areas of synthetic and biological materials and structures. At this level, mechanical properties are intimately related to chemistry, physics, and quantum mechanics. Most lectures will consist of a theoretical component that will then be compared to recent experimental data (case studies) in the literature. The course begins with a series of introductory lectures that describes the normal and lateral forces acting at the atomic scale. The following discussions include experimental techniques in high resolution force spectroscopy, atomistic aspects of adhesion, nanoindentation, molecular details of fracture, chemical force microscopy, elasticity of single macromolecular chains, intermolecular interactions in polymers, dynamic force spectroscopy, biomolecular bond strength measurements, and molecular motors.

Subject:
Biology
Chemistry
Genetics
Life Science
Physical Science
Physics
Material Type:
Full Course
Provider:
M.I.T.
Provider Set:
M.I.T. OpenCourseWare
Author:
Ortiz, Christine
Date Added:
01/01/2007
Nutrigenomics: An Interface of Gene-Diet-Disease Interaction
Unrestricted Use
CC BY
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This is a peer-reviewed chapter in an open access book, Mineral Deficiencies. This chapter serves as an introduction to the emerging field of nutrigenomics (NG), a specialized branch of nutritional research which examines gene-diet interactions and its role in chronic disease. The chapter highlights the effects of specific food components on the genes which predispose individuals to chronic diseases such as: obesity, CVD, diabetes and cancer. The chapter does contain some grammatical and spelling errors, but the information contained is clear and relevant. It is a technical reading that is best suited to nurses, physicians, nutritionists, and other allied health professionals at both the undergraduate and graduate level.

Subject:
Applied Science
Genetics
Health, Medicine and Nursing
Life Science
Nutrition
Material Type:
Reading
Author:
Debasish Panda
Sananda Mondal
Date Added:
12/07/2022
Pedigrees and the Inheritance of Lactose Intolerance
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Educational Use
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In this activity students analyze a family’s pedigrees to make a claim based on evidence about mode of inheritance of a lactose intolerance trait, determine the most likely inheritance pattern of a trait, and analyze variations in DNA to make a claim about which variants are associated with specific traits. This activity serves as a supplement to the film Got Lactose? The Co-evolution of Genes and Culture (http://www.hhmi.org/biointeractive/making-fittest-got-lactase-co-evolution-genes-and-culture). The film shows a scientist as he tracks down the genetic changes associated with the ability to digest lactose as adults. A detailed teacher’s guide that includes curriculum connections, teaching tips, time requirements, answer key and a student guide can be downloaded at http://www.hhmi.org/biointeractive/pedigrees-and-inheritance-lactose-intolerance. Six supporting resource and two “click and learn” activities are also found on the link.

Subject:
Applied Science
Biology
Genetics
Health, Medicine and Nursing
Life Science
Material Type:
Lesson Plan
Provider:
National Science Teachers Association (NSTA)
Provider Set:
NGSS@NSTA
Date Added:
07/07/2021
Personalized Care: Prevention of Lifestyle Diseases
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CC BY-NC
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This is a peer-reviewed chapter in an open access book, Personalized Medicine in Relation to Redox State, Diet and Lifestyle. Several diet-related conditions where personalized care can revolutionize treatment, control and prevention of lifestyle diseases are discussed (Type II diabetes, obesity, cardiovascular diseases, cancer, oral health and osteoporosis). This chapter serves as an introductory overview of the subject. The chapter is accurate, relevant and clear. It is a technical reading that is best suited to nurses, nutritionists and other allied health professionals at both the undergraduate and graduate level.

Subject:
Applied Science
Genetics
Health, Medicine and Nursing
Life Science
Nutrition
Material Type:
Reading
Author:
Shakir Ali
Tijani Saliju Shinkafi
Written By
Date Added:
12/07/2022
Quantitative Genomics, Fall 2005
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CC BY-NC-SA
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Subject assesses the relationships between sequence, structure, and function in complex biological networks as well as progress in realistic modeling of quantitative, comprehensive functional-genomics analyses. Topics include: algorithmic, statistical, database, and simulation approaches; and practical applications to biotechnology, drug discovery, and genetic engineering. Future opportunities and current limitations critically assessed. Problem sets and project emphasize creative, hands-on analyses using these concepts.

Subject:
Biology
Genetics
Life Science
Material Type:
Full Course
Provider:
M.I.T.
Provider Set:
M.I.T. OpenCourseWare
Author:
Berwick, Robert
Kho, Alvin
Kohane, Isaac
Mirny, Leonid
Date Added:
01/01/2005
A Recipe for Traits
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Educational Use
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Students create and decode DNA for man’s best friend to observe how variations in DNA lead to the inheritance of different traits. Strips of paper that represent DNA are randomly selected and used to assemble the dog's DNA. Students read the DNA and create a drawing of their pet, and compare it with others in the class to check for similarities and differences.

Subject:
Biology
Genetics
Life Science
Material Type:
Activity/Lab
Provider:
National Science Teachers Association (NSTA)
Provider Set:
NGSS@NSTA
Date Added:
07/07/2021
Restriction Enzymes and DNA Fingerprinting
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Educational Use
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The discovery of restriction enzymes and their applications in DNA analysis has proven to be essential for biologists and chemists. This lesson focuses on restriction enzymes and their applications to DNA analysis and DNA fingerprinting. Use this lesson and its associated activity in conjunction with biology lessons on DNA analysis and DNA replication.

Subject:
Applied Science
Engineering
Genetics
Life Science
Physical Science
Physics
Material Type:
Lesson Plan
Provider:
TeachEngineering
Provider Set:
TeachEngineering
Author:
Mircea Ionescu
Myla Van Duyn
Date Added:
09/18/2014
Show Me the Genes
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Educational Use
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By this point in the unit, students have learned all the necessary information and conceptualized a design for how an optical biosensor could be used to detect a target strand of DNA associated with a cancer-causing gene as their solution to the unit's challenge question. Now student groups act as engineers again, using a poster format to communicate and prove the validity of the design. Successful posters include a description of refraction, explanations of refraction in a thin film, and the factors that can alter the interference pattern of a thin film. The posters culminate with an explanation of what is expected to be seen in a biosensing device of this type if it were coupled to a target molecule, proven with a specific example and illustrated with drawings and diagrams throughout. All the poster elements combine to prove the accuracy and viability of this method of gene detection. Together with its associated lesson, this activity functions as part of the summative assessment for this unit.

Subject:
Applied Science
Engineering
Genetics
Life Science
Material Type:
Activity/Lab
Provider:
TeachEngineering
Provider Set:
TeachEngineering
Author:
Caleb Swartz
Date Added:
09/18/2014
Special Topics: Genetics, Neurobiology, and Pathophysiology of Psychiatric Disorders, Fall 2008
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CC BY-NC-SA
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An opportunity for graduate study of advanced subjects in Brain and Cognitive Sciences not included in other subject listings. The key topics covered in this course are Bipolar Disorder, Psychosis, Schizophrenia, Genetics of Psychiatric Disorder, DISC1, Ca++ Signaling, Neurogenesis and Depression, Lithium and GSK3 Hypothesis, Behavioral Assays, CREB in Addiction and Depressive Behaviors, The GABA System-I, The GABA System-II, The Glutamate Hypothesis of Schizophrenia, The Dopamine Pathway and DARPP32.

Subject:
Biology
Genetics
Life Science
Material Type:
Full Course
Provider:
M.I.T.
Provider Set:
M.I.T. OpenCourseWare
Author:
Scolnick, Edward
Tsai, Li-Huei
Date Added:
01/01/2008
Stretching DNA
Unrestricted Use
CC BY
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Explore stretching just a single strand of DNA using optical tweezers or fluid flow. Experiment with the forces involved and measure the relationship between the stretched DNA length and the force required to keep it stretched. Is DNA more like a rope or like a spring?

Subject:
Genetics
Life Science
Material Type:
Simulation
Provider:
University of Colorado Boulder
Provider Set:
PhET Interactive Simulations
Author:
Chris Malley
Kathy Perkins
Meredith Betterton
Mike Dubson
Tom Perkins
Wendy Adams
Date Added:
12/01/2007