This course covers all aspects of molecular biosignatures, such as their pathways of lipid biosynthesis, the distribution patterns of lipid biosynthetic pathways with regard to phylogeny and physiology, isotopic contents, occurrence in modern organisms and environments, diagenetic pathways, analytical techniques and the occurrence of molecular fossils through the geological record. Students analyze in depth the recent literature on chemical fossils. Lectures provide background on the subject matter. Basic knowledge of organic chemistry required. Students taking graduate version complete additional assignments.

Detailed analysis of the biochemical mechanisms that control the maintenance, expression, and evolution of prokaryotic and eukaryotic genomes. Topics covered in lecture and readings of relevant literature include: gene regulation, DNA replication, genetic recombination, and translation. Logic of experimental design and data analysis emphasized. Presentations include both lectures and group discussions of representative papers from the literature.

An introductory course in the molecular biology of the auditory system. First half focuses on human genetics and molecular biology, covering fundamentals of pedigree analysis, linkage analysis, molecular cloning, and gene analysis as well as ethical/legal issues, all in the context of an auditory disorder. Second half emphasizes molecular approaches to function and dysfunction of the cochlea, and is based on readings and discussion of research literature.

This course develops and applies scaling laws and the methods of continuum and statistical mechanics to biomechanical phenomena over a range of length scales, from molecular to cellular to tissue or organ level.

This course covers the analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of state-of-the-art materials science to problems in tissue engineering, drug delivery, vaccines, and cell-guiding surfaces.

Basic molecular structural principles of biological materials. Molecular structures of various materials of biological origin, including collagen, silk, bone, protein adhesives, GFP, self-assembling peptides. Molecular design of new biological materials for nanotechnology, biocomputing and regenerative medicine. Graduate students are expected to complete additional coursework. This course, intended for both graduate and upper level undergraduate students, will focus on understanding of the basic molecular structural principles of biological materials. It will address the molecular structures of various materials of biological origin, such as several types of collagen, silk, spider silk, wool, hair, bones, shells, protein adhesives, GFP, and self-assembling peptides. It will also address molecular design of new biological materials applying the molecular structural principles. The long-term goal of this course is to teach molecular design of new biological materials for a broad range of applications. A brief history of biological materials and its future perspective as well as its impact to the society will also be discussed. Several experts will be invited to give guest lectures.

This courses focuses on the fundamentals of tissue and organ response to injury from a molecular and cellular perspective. There is a special emphasis on disease states that bridge infection, inflammation, immunity, and cancer. The systems approach to pathophysiology includes lectures, critical evaluation of recent scientific papers, and student projects and presentations. This term, we focus on hepatocellular carcinoma (HCC), chronic-active hepatitis, and hepatitis virus infections. In addition to lectures, students work in teams to critically evaluate and present primary scientific papers.

Money Moves helps students develop strategies for managing their finances through online and mobile banking tools. Students will learn to make wise decisions that support their current and future financial well-being, with an emphasis on safe and responsible use of virtual payment apps. This includes identifying scams or attempted fraud online, determining methods of controlling personal information to practice safe internet usage, and summarizing the risks and protections of virtual payment applications.

This course will focus on issues that arise in contemporary public debate concerning matters of social justice. Topics will likely include: euthanasia, gay marriage, racism and racial profiling, free speech, hunger and global inequality. Students will be exposed to multiple points of view on the topics and will be given guidance in analyzing the moral frameworks informing opposing positions. The goal will be to provide the basis for respectful and informed discussion of matters of common moral concern.

This course is an examination of philosophical theories of action and motivation in the light of empirical findings from social psychology, sociology, and neuroscience. Topics include belief, desire, and moral motivation; sympathy and empathy; intentions and other committing states; strength of will and weakness of will; free will; addiction and compulsion; guilt, shame and regret; evil; self-knowledge and self-deception; and, virtues and character traits. This course is a CI-M course.

Presents a rational basis for the preliminary design of motion-sensitive structures. Topics include: analytical and numerical techniques for establishing the optimal stiffness distribution, the role of damping in controlling motion, tuned mass dampers, base isolation systems, and an introduction to active structural control. Examples illustrating the application of the motion-based design paradigm to building structures subjected to wind and seismic excitation are discussed.

Multi-scale systems differ from traditional macro-scale systems in that the multi-scale systems use components from two or more scales (i.e. nano, micro, meso, and macro-scales). Subject provides the skills required to design and manufacture multi-scale systems. Emphasis is placed on understanding the fundamental differences between traditional macro-scale system design and the design of multi-scale systems. Topics include design methodologies, modeling approaches, analytic tools, and manufacturing processes. Examples drawn from a diverse range of applications, including automobiles, fiber optic equipment, electronic test equipment, and micro/meso-scale machinery. Students master the materials through problem sets and a substantial term project.

Languages and compilers to exploit multithreaded parallelism. Implicit parallel programming using functional languages and their extensions. Higher-order functions, non-strictness, and polymorphism. Explicit parallel programming and nondeterminism. The lambda calculus and its variants. Term rewriting and operational semantics. Compiling multithreaded code for symmetric multiprocessors and clusters. Static analysis and compiler optimizations.

This course covers differential, integral and vector calculus for functions of more than one variable. These mathematical tools and methods are used extensively in the physical sciences, engineering, economics and computer graphics.

This course is a continuation of 18.014. It covers the same material as 18.02 (Multivariable Calculus), but at a deeper level, emphasizing careful reasoning and understanding of proofs. There is considerable emphasis on linear algebra and vector integral calculus.

Computer-aided design methodologies for synthesis of multivariable feedback control systems. Performance and robustness trade-offs. Model-based compensators; Q-parameterization; ill-posed optimization problems; dynamic augmentation; linear-quadratic optimization of controllers; H-infinity controller design; Mu-synthesis; model and compensator simplification; nonlinear effects. Computer-aided (MATLAB) design homework using models of physical processes. This course uses computer-aided design methodologies for synthesis of multivariable feedback control systems. Topics covered include: performance and robustness trade-offs; model-based compensators; Q-parameterization; ill-posed optimization problems; dynamic augmentation; linear-quadratic optimization of controllers; H-infinity controller design; Mu-synthesis; model and compensator simplification; and nonlinear effects. The assignments for the course comprise of computer-aided (MATLABĺ¨) design problems.

Growth and development of normal bone and joints, the process of mineralization, the biophysics of bone and response to stress and fracture, calcium and phosphate homeostasis and regulation by parathyroid hormone and vitamin D, and the pathogenesis of metabolic bone diseases and disease of connective tissue, joints, and muscles, with consideration of possible mechanisms and underlying metabolic derangements.

Welcome to Music 101.  I think you’ve made a smart choice to spend some weeks studying some of the greatest music ever written.  Consider for a moment how quickly a hit pop song passes from fashionable to forgotten.  Those of us that have been out of high school or college more years than we care to remember have certainly had the experience of hearing a favorite anthem of our youth and thinking, “Oh yeah, that song!  I’d forgotten that one.”  Think about that: the song was totally loved, then completely forgotten within a matter of just a few years.  Then consider that many of the composers that we will study have been dead for over two hundred years, and yet their music has never been forgotten and never stopped being performed and loved.  That, quite simply, is amazing.

This course is an exposition of the philosophy, principles, and materials of music from the Baroque Period to contemporary period with illustrative examples from the Baroque Period, Classical Period, Romantic Period, Contemporary Classical Music and Popular Music. The course is designed to give the student an appreciation of music by exposing them to many musical styles, composers, historical trends, as well as increasing their aural, verbal and writing skills in describing music.

Music is an important part of human experience and the unending desire to express oneself in creative and imaginative ways. The purpose of this course is to help students further enhance their appreciation for music as a creative tool of the imagination, as entertainment, and as a window into who we are as social beings. Part of the course also helps students to advance their listening skills, which leads to a better understand of what music actually contains. For this purpose, the course explores western classical music; American folk, popular and religious music; along with a sampling of music from non-western cultures. Login: guest_oclPassword: ocl