Detailed analysis of the biochemical mechanisms that control the maintenance, expression, and evolution of prokaryotic and eukaryotic genomes. Topics covered in lecture and readings of relevant literature include: gene regulation, DNA replication, genetic recombination, and translation. Logic of experimental design and data analysis emphasized. Presentations include both lectures and group discussions of representative papers from the literature.

An introductory course in the molecular biology of the auditory system. First half focuses on human genetics and molecular biology, covering fundamentals of pedigree analysis, linkage analysis, molecular cloning, and gene analysis as well as ethical/legal issues, all in the context of an auditory disorder. Second half emphasizes molecular approaches to function and dysfunction of the cochlea, and is based on readings and discussion of research literature.

This course develops and applies scaling laws and the methods of continuum and statistical mechanics to biomechanical phenomena over a range of length scales, from molecular to cellular to tissue or organ level.

This course covers the analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of state-of-the-art materials science to problems in tissue engineering, drug delivery, vaccines, and cell-guiding surfaces.

Basic molecular structural principles of biological materials. Molecular structures of various materials of biological origin, including collagen, silk, bone, protein adhesives, GFP, self-assembling peptides. Molecular design of new biological materials for nanotechnology, biocomputing and regenerative medicine. Graduate students are expected to complete additional coursework. This course, intended for both graduate and upper level undergraduate students, will focus on understanding of the basic molecular structural principles of biological materials. It will address the molecular structures of various materials of biological origin, such as several types of collagen, silk, spider silk, wool, hair, bones, shells, protein adhesives, GFP, and self-assembling peptides. It will also address molecular design of new biological materials applying the molecular structural principles. The long-term goal of this course is to teach molecular design of new biological materials for a broad range of applications. A brief history of biological materials and its future perspective as well as its impact to the society will also be discussed. Several experts will be invited to give guest lectures.

This courses focuses on the fundamentals of tissue and organ response to injury from a molecular and cellular perspective. There is a special emphasis on disease states that bridge infection, inflammation, immunity, and cancer. The systems approach to pathophysiology includes lectures, critical evaluation of recent scientific papers, and student projects and presentations. This term, we focus on hepatocellular carcinoma (HCC), chronic-active hepatitis, and hepatitis virus infections. In addition to lectures, students work in teams to critically evaluate and present primary scientific papers.

This course will focus on issues that arise in contemporary public debate concerning matters of social justice. Topics will likely include: euthanasia, gay marriage, racism and racial profiling, free speech, hunger and global inequality. Students will be exposed to multiple points of view on the topics and will be given guidance in analyzing the moral frameworks informing opposing positions. The goal will be to provide the basis for respectful and informed discussion of matters of common moral concern.

This course is an examination of philosophical theories of action and motivation in the light of empirical findings from social psychology, sociology, and neuroscience. Topics include belief, desire, and moral motivation; sympathy and empathy; intentions and other committing states; strength of will and weakness of will; free will; addiction and compulsion; guilt, shame and regret; evil; self-knowledge and self-deception; and, virtues and character traits. This course is a CI-M course.

Presents a rational basis for the preliminary design of motion-sensitive structures. Topics include: analytical and numerical techniques for establishing the optimal stiffness distribution, the role of damping in controlling motion, tuned mass dampers, base isolation systems, and an introduction to active structural control. Examples illustrating the application of the motion-based design paradigm to building structures subjected to wind and seismic excitation are discussed.

Multi-scale systems differ from traditional macro-scale systems in that the multi-scale systems use components from two or more scales (i.e. nano, micro, meso, and macro-scales). Subject provides the skills required to design and manufacture multi-scale systems. Emphasis is placed on understanding the fundamental differences between traditional macro-scale system design and the design of multi-scale systems. Topics include design methodologies, modeling approaches, analytic tools, and manufacturing processes. Examples drawn from a diverse range of applications, including automobiles, fiber optic equipment, electronic test equipment, and micro/meso-scale machinery. Students master the materials through problem sets and a substantial term project.

Languages and compilers to exploit multithreaded parallelism. Implicit parallel programming using functional languages and their extensions. Higher-order functions, non-strictness, and polymorphism. Explicit parallel programming and nondeterminism. The lambda calculus and its variants. Term rewriting and operational semantics. Compiling multithreaded code for symmetric multiprocessors and clusters. Static analysis and compiler optimizations.

This course covers differential, integral and vector calculus for functions of more than one variable. These mathematical tools and methods are used extensively in the physical sciences, engineering, economics and computer graphics.

This course is a continuation of 18.014. It covers the same material as 18.02 (Multivariable Calculus), but at a deeper level, emphasizing careful reasoning and understanding of proofs. There is considerable emphasis on linear algebra and vector integral calculus.

Computer-aided design methodologies for synthesis of multivariable feedback control systems. Performance and robustness trade-offs. Model-based compensators; Q-parameterization; ill-posed optimization problems; dynamic augmentation; linear-quadratic optimization of controllers; H-infinity controller design; Mu-synthesis; model and compensator simplification; nonlinear effects. Computer-aided (MATLAB) design homework using models of physical processes. This course uses computer-aided design methodologies for synthesis of multivariable feedback control systems. Topics covered include: performance and robustness trade-offs; model-based compensators; Q-parameterization; ill-posed optimization problems; dynamic augmentation; linear-quadratic optimization of controllers; H-infinity controller design; Mu-synthesis; model and compensator simplification; and nonlinear effects. The assignments for the course comprise of computer-aided (MATLABĺ¨) design problems.

Growth and development of normal bone and joints, the process of mineralization, the biophysics of bone and response to stress and fracture, calcium and phosphate homeostasis and regulation by parathyroid hormone and vitamin D, and the pathogenesis of metabolic bone diseases and disease of connective tissue, joints, and muscles, with consideration of possible mechanisms and underlying metabolic derangements.

Directed composition of larger forms of original writing involving voices and/or instruments. Includes a weekly seminar in composition for the presentation and discussion of student work in progress. Students are expected to produce at least one substantive work, performed in public, by the end of the term. Contemporary compositions and major works from twentieth-century music literature are studied. Meets with graduate subject 21M.505, but assignments vary.

This course is a survey of perceptual and cognitive aspects of the psychology of music, with special emphasis on underlying neuronal and neurocomputational representations and mechanisms. Basic perceptual dimensions of hearing (pitch, timbre, consonance/roughness, loudness, auditory grouping) form salient qualities, contrasts, patterns and streams that are used in music to convey melody, harmony, rhythm and separate voices. Perceptual, cognitive, and neurophysiological aspects of the temporal dimension of music (rhythm, timing, duration, temporal expectation) are explored. Special topics include comparative, evolutionary, and developmental psychology of music perception, biological vs. cultural influences, Gestaltist vs. associationist vs. schema-based theories, comparison of music and speech perception, parallels between music cognition and language, music and cortical action, and the neural basis of music performance.

Begins with the premise that the 1960s mark a great dividing point in the history of twentieth-century Western musical culture, and explores the ways in which various social and artistic concerns of composers, performers, and listeners have evolved since that decade. Focuses on works by classical composers from around the world. Topics to be explored include: the impact of rock, as it developed during the 1960s-70s; the concurrent emergence of post-serial, neo-tonal, Minimalist, and New Age styles; the globalization of Western musical traditions; the impact of new technologies; and the significance of music video, video games, and other versions of (digital) multimedia. Interweaves discussion of these topics with close study of seminal musical works, evenly distributed across the four decades since 1960. Works by MIT composers included.

An introduction to the analysis of tonal music. Students develop analytical techniques based upon concepts learned in Harmony and Counterpoint I and II. Students study harmony, counterpoint, melodic line and motivic relationships at local and large scale levels of musical structure. Three 7-page papers, one revised paper, and one oral presentation required.

This course examines the history, techniques, and aesthetics of mechanical and computer-aided approaches to algorithmic music composition and generative music systems. Through creative hands-on projects, readings, listening assignments, and lectures, students will explore a variety of historical and contemporary approaches. Diverse tools and systems will be employed, including applications in Python, MIDI, Csound, SuperCollider, and Pure Data.