Tumor pathophysiology plays a central role in the growth, metastasis, detection, and treatment of solid tumors. Principles of transport phenomena are applied to develop a quantitative understanding of angiogenesis (formation of new blood vessels), blood flow and microcirculation, metabolism and microenvironment, transport and binding of small and large molecules, movement of cancer and immune cells, metastatic process, radiotherapy, chemotherapy, immunotherapy, hyperthermia, and photodynamic therapy of solid tumors.

Cancer is a leading cause of death worldwide. Cancer involves uncontrolled cell growth, resistance to cell death, failure to differentiate into a particular cell type, and increased cellular motility. A family of gate-keeper genes, known as tumor suppressor genes, plays important roles in preventing the initiation and progression of cancer. Among these, p53 is the most famous. Because of its essential role in maintaining genomic integrity, p53 is often called the guardian of the genome. During this course, we will study how p53 serves as a pivotal tumor suppressor gene in preventing cancer.This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.

Students apply their knowledge about mountains and rocks to transportation engineering, with the task of developing a model mountain tunnel that simulates the principles behind real-life engineering design. Student teams design and create model tunnels through a clay mountain, working within design constraints and testing for success; the tunnels must meet specific design requirements and withstand a certain load.

This course presents the phenomena, theory, and modeling of turbulence in the Earth's oceans and atmosphere. The scope ranges from centimeter to planetary scale motions. The regimes of turbulence include homogeneous isotropic three dimensional turbulence, convection, quasi-geotropic turbulence, shallow water turbulence, baroclinic turbulence, macro turbulence in the ocean and atmosphere.

This art history video discussion looks at "Joseph Mallord William Turner, Rain, Steam, and Speed -- The Great Western Railway", oil on canvas, 1844 (National Gallery, London). It depicts the Maidenhead Railway Bridge (completed (1838) looking east, across the River Thames between Taplow and Maidenhead.

This art history video looks at Joseph Mallord William Turner" "Slave Ship (Slavers Throwing Overboard the Dead and Dying, Typhoon Coming On" from 1840. Oil on canvas, Museum of Fine Arts, Boston.

Students develop their understanding of air convection currents and temperature inversions by constructing and observing simple models.

The Folger Shakespeare Library provides the full searchable text of "Twelfth Night" to read online or download as a PDF. All of the lines are numbered sequentially to make it easier and more convenient to find any line.

The classic American drama Twelve Angry Men can be used to frame discussion of the constitutional right and civic function of the trial by jury. The lesson explores the specific provisions associated with this right as well as the strengths and weaknesses of the system.

The corrupting influence of slavery on marriage and the family is a predominant theme in Solomon Northup's narrative Twelve Years a Slave. In this lesson, students are asked to identify and analyze narrative passages that provide evidence for how slavery undermined and perverted these social institutions. Northup collaborated with a white ghostwriter, David Wilson. Students will read the preface and identify and analyze statements Wilson makes to prove the narrative is true.

This lesson focuses on the slave narrative of Solomon Northup, a free black living in the North, who was kidnapped and sold into slavery in the Deep South. Slave narratives are autobiographies of former slaves that describe their experiences during enslavement, how they became free, and their lives in freedom. Because slave narratives treat the experience of one person, they raise questions about whether that individual's experiences exceptional.

Students build their own two-cell batteries. They also determine which electrolyte solution is best suited for making batteries.

Both of the questions in this task are solved by the division problem 12Ö3 but what happens to the ribbon is different in each case.

In this task, we are given the graph of two lines including the coordinates of the intersection point and the coordinates of the two vertical intercepts, and are asked for the corresponding equations of the lines. It is a very straightforward task that connects graphs and equations and solutions and intersection points.

This task provides an opportunity for students to construct linear and exponential functions, including arithmetic and geometric sequences, given a graph, a description of a relationship, or two input-output pairs (include reading these from a table).

This task provides an opportunity for students to construct linear and exponential functions, including arithmetic and geometric sequences, given a graph, a description of a relationship, or two input-output pairs (include reading these from a table).

This art history video features a conversation between Dr. Elizabeth Macaulay-Lewis and Dr. Steven Zucker in front of "Two Royal Figures," Iran (Saljuq period), mid 11th - mid 12th c., painted and gilded stucco (Metropolitan Museum of Art).

Students learn more about magnetism, and how magnetism and electricity are related in electromagnets. They learn the fundamentals about how simple electric motors and electromagnets work. Students also learn about hybrid gasoline-electric cars and their advantages over conventional gasoline-only-powered cars.

This classroom task is meant to elicit a variety of different methods of solving a quadratic equation (A-REI.4).

This short video and interactive assessment activity is designed to give fourth graders an overview of metric capacity operations.