Immune cells protect our bodies from both self-derived threats and exogenous pathogens, while keeping peace with normal cells and non-harmful commensal microbiota. They have various mechanisms to perform these tasks, a capacity that is essential for maintaining homeostasis. However, these same mechanisms can backfire, resulting in severe disorders such as immunodeficiency, chronic inflammation, allergy, degenerative diseases, and cancer. This course discusses the connections between normal physiology and disease by examining the developmental relationship between innate and adaptive immune cells as well as the functions and malfunctions of immune cells. The course familiarizes students with both basic biological principles (such as cell death and immune cell signaling) and clinical applications (such as immune checkpoint blockade). More generally, students learn to identify relevant primary research literature, critically evaluate experimental data, and reach their own conclusions based on primary data.

Explore tunneling splitting in double well potentials. This classic problem describes many physical systems, including covalent bonds, Josephson junctions, and two-state systems such as spin 1/2 particles and ammonia molecules.

This task would be especially well-suited for instructional purposes. Students will benefit from a class discussion about the slope, y-intercept, x-intercept, and implications of the restricted domain for interpreting more precisely what the equation is modeling.

Focuses on the role of the business improvement district (BID) as a popular and contemporary tool for urban revitalization. Explores BID origins, theoretical underpinnings, enabling legislation, and organizational issues. Emphasizes BID service provision including advocacy, marketing, sanitation, streetscape improvement, security and transportation, while examining BID performance using such indicators as crime rates, vacancy rates, and retail sales. Considers BID organizations throughout North America as well as comparable schemes in Australia, Holland, Japan, New Zealand, South Africa, and the United Kingdom. This course focuses on the origins, functions, and implications of downtown management organizations (DMOs), such as business improvement districts, in a variety of national contexts including the United States, Canada, South Africa, and the United Kingdom. It critically examines how a range of urban theories provide a rationale for the establishment and design of DMOs; the evolution and transnational transfer of DMO policy; and the spatial and political externalities associated with the local proliferation of DMOs. Particular emphasis is given to the role of DMOs in securing public space.

Seminar on downtown in US cities from the late nineteenth century to the late twentieth. Emphasis on downtown as an idea, place, and cluster of interests, on the changing character of downtown, and on recent efforts to rebuild it. Subjects considered include subways, skyscrapers, highways, urban renewal, and retail centers. Focus on readings, discussions, and individual research projects. Meets with graduate subject 11.339, but assignments differ.

Students see how surface tension can enable light objects (paper clips, peppercorns) to float on an island of oil in water, and subsequently sink when the surface tension of the oil/water interface is reduced by the addition of a surfactant; such as ordinary dish soap.

Students will listen to a brief biography, view photographs of the March on Washington, hear a portion of King's "I Have a Dream" speech, and discuss what King's words mean to them.

By closely reading historical documents and attempting to interpret them, students consider how Arthur Miller interpreted the facts of the Salem witch trials and how he successfully dramatized them in his play, "The Crucible." As they explore historical materials, such as the biographies of key players (the accused and the accusers) and transcripts of the Salem Witch trials themselves, students will be guided by aesthetic and dramatic concerns: In what ways do historical events lend themselves (or not) to dramatization? What makes a particular dramatization of history effective and memorable?

Students practice creating rudimentary detail drawings. They learn how engineers communicate the technical information about their designs using the basic components of detail drawings. They practice creating their own drawings of a three-dimensional block and a special LEGO piece, and then make 3D sketches of an unknown object using only the information provided in its detail drawing.

Seminar on a selected topic from Renaissance architecture. Requires original research and presentation of a report. The aim of this course is to highlight some technical aspects of the classical tradition in architecture that have so far received only sporadic attention. It is well known that quantification has always been an essential component of classical design: proportional systems in particular have been keenly investigated. But the actual technical tools whereby quantitative precision was conceived, represented, transmitted, and implemented in pre-modern architecture remain mostly unexplored. By showing that a dialectical relationship between architectural theory and data-processing technologies was as crucial in the past as it is today, this course hopes to promote a more historically aware understanding of the current computer-induced transformations in architectural design.

This Super Lesson utilizes Project Based Learning to assist learners with designing, building, and testing flying contraptions as an introduction to Engineering. The goal of this project is to engage students in collaborative team work and to introduce students to the Science and Engineering Practices: Asking Questions and Defining Problems, Planning and Carrying Out Investigations, and Constructing Explanations and Designing Solutions.

We have offered this Super Lesson as an 8-week elective course, developing and strengthening student interest in applied Math and Science topics. It could also be offered within upper elementary or middle school Science and Math courses. In addition, each week’s topic could be used as a stand alone mini-lesson if time is limited. We have worked to include multiple options within this unit to make it accessible to both general education and special education programs, including recommendations for modifications and extensions.

In dredging, production estimating is carried out mainly with analytical physical models of the different dredging processes.
Slurry transport of settling slurries and cutting processes in sand, clay and rock are already covered in two other books by the author.
Other processes like hopper sedimentation and erosion, water jet fluidization, cutter head spillage, pump/pipeline dynamics and clamshell dredging are covered in this Special Topics Edition.
New topics may be added in the near future.

The course focuses on three main dredging processes: the cutting of sand, clay and rock, the sedimentation process in hopper dredges and the breaching process

The purpose of this course is to convey knowledge of the various physical processes associated with slurry handling and transport during dredging. This knowledge is needed for the design of dredging equipment and for planning efficient equipment operations. The various processes are discussed and theories and simulation models that describe the processes are presented and compared during the course. The course can be broken down into four elements: 1. Pumps and engines a. Pump characteristics and cavitation b. Influence of particles on pump characteristics. 2. Hydraulic transport in pipelines a. Two-phase (solid-liquid) flow through pipelines b. Newtonian slurries c. Non Newtonian slurries d. Inclined and long pipelines. 3. Pump and pipeline systems a. Operation point and areas b. Production factors. 4. Case studies

In this design activity, students investigate materials engineering as it applies to weather and clothing. Teams design and analyze different combinations of materials for effectiveness in specific weather conditions. Analysis includes simulation of temperature, wind and wetness elements, as well as the functionality and durability of final prototypes.

This activity is a teacher-led demonstration of continental drift and includes a math worksheet for students involving the calculation of continental drift over time. Students will understand what continental drift is, why it occurs, and how earthquakes occur because of it.

This problem involves fraction multiplication that can be solved with pictures or number lines.

This task builds on a fifth grade fraction multiplication task and uses the identical context, but asks the corresponding ŇNumber of Groups UnknownÓ division problem.