Medicines By Design aims to explain how scientists unravel the many different …
Medicines By Design aims to explain how scientists unravel the many different ways medicines work in the body and how this information guides the hunt for drugs of the future. Pharmacology is a broad discipline encompassing every aspect of the study of drugs, including their discovery and development and the testing of their action in the body. Much of the most promising pharmacological research going on at universities across the country is sponsored by the National Institute of General Medical Sciences (NIGMS), a component of the National Institutes of Health (NIH), U.S. Department of Health and Human Services. Working at the crossroads of chemistry, genetics, cell biology, physiology, and engineering, pharmacologists are fighting disease in the laboratory and at the bedside.
Students obtain a basic understanding of microfluidic devices, how they are developed …
Students obtain a basic understanding of microfluidic devices, how they are developed and their uses in the medical field. After conducting the associated activity, they watch a video clip and learn about flow rate and how this relates to the speed at which medicine takes effect in the body. What they learn contributes to their ongoing objective to answer the challenge question presented in lesson 1 of this unit. They conclude by solving flow rate problems provided on a worksheet.
Principles of tomographic imaging using ionizing and non-ionizing radiation, and ultrasound. Emphasis …
Principles of tomographic imaging using ionizing and non-ionizing radiation, and ultrasound. Emphasis is placed on fundamental physics and mathematics involved in image formation, including basic interactions, data acquisition and reconstruction. Planar radiographic imaging, multi-dimensional tomography (X-ray CAT, PET, SPECT), ultrasound, and NMR imaging covered. 22.56J aims to give graduate students and advanced undergraduates background in the theory and application of noninvasive imaging methods to biology and medicine, with emphasis on neuroimaging. The course focuses on the modalities most frequently used in scientific research (X-ray CT, PET/SPECT, MRI, and optical imaging), and includes discussion of molecular imaging approaches used in conjunction with these scanning methods. Lectures by the professor will be supplemented by in-class discussions of problems in research, and hands-on demonstrations of imaging systems.
Through this lesson and its associated activity, students explore the role of …
Through this lesson and its associated activity, students explore the role of biomedical engineers working for pharmaceutical companies. First, students gain background knowledge about what biomedical engineers do, how to become a biomedical engineer, and the steps of the engineering design process. The goal is to introduce biomedical engineering as medical problem solving as well as highlight the importance of maintaining normal body chemistry. Students participate in the research phase of the design process as it relates to improving the design of a new prescription medication. During the research phase, engineers learn about topics by reading scholarly articles written by others, and students experience this process. Students draw on their research findings to participate in discussion and draw conclusions about the impact of medications on the human body.
In a class demonstration, the teacher places different pill types ("chalk" pill, …
In a class demonstration, the teacher places different pill types ("chalk" pill, gel pill, and gel tablet) into separate glass beakers of vinegar, representing human stomach acid. After 20-30 minutes, the pills dissolve. Students observe which dissolve the fastest, and discuss the remnants of the various pills. What they learn contributes to their ongoing objective to answer the challenge question presented in lesson 1 of this unit.
Subject provides a comprehensive overview of human pathology with emphasis on mechanisms …
Subject provides a comprehensive overview of human pathology with emphasis on mechanisms of disease and modern diagnostic technologies. Topics include: general mechanisms of disease (inflammation, infection, immune injury, host response to foreign materials, transplantation, genetic disorders and neoplasia); pathology of lipids, enzymes, and molecular transporters; pathology of major organ systems; and review of diagnostic tools from invasive surgical pathology to non-invasive techniques such as optical spectroscopy, functional imaging, and molecular markers of disease. The objectives of this subject are achieved by a set of integrated lectures and laboratories, as well as a student-driven term project leading to a formal presentation on a medical, socioeconomic, or technological issue in human pathology.
Students reinforce their knowledge of the different parts of the digestive system …
Students reinforce their knowledge of the different parts of the digestive system and explore the concept of simulation by developing a pill coating that can withstand the churning actions and acidic environment found in the stomach. Teams test the coating durability by using a clear soda to simulate stomach acid.
Students experience the steps of the engineering design process as they design …
Students experience the steps of the engineering design process as they design solutions for a real-world problem that could affect their health. After a quick review of the treatment processes that municipal water goes through before it comes from the tap, they learn about the still-present measurable contamination of drinking water due to anthropogenic (human-made) chemicals. Substances such as prescription medication, pesticides and hormones are detected in the drinking water supplies of American and European metropolitan cities. Using chlorine as a proxy for estrogen and other drugs found in water, student groups design and test prototype devices that remove the contamination as efficiently and effectively as possible. They use plastic tubing and assorted materials such as activated carbon, cotton balls, felt and cloth to create filters with the capability to regulate water flow to optimize the cleaning effect. They use water quality test strips to assess their success and redesign for improvement. They conclude by writing comprehensive summary design reports.
A framework of public hygiene and epidemiology is given. Human pathology related …
A framework of public hygiene and epidemiology is given. Human pathology related to water and sanitation is dealt with, as well as the relation between health and society and environment.
Laboratory or field work in earth, atmospheric, and planetary sciences. To be …
Laboratory or field work in earth, atmospheric, and planetary sciences. To be arranged with department faculty. Consult with department Education Office. This course introduces fundamentals of radon physics, geology, radiation biology; provides hands on experience of measurement of radon in MIT environments, and discusses current radon research in the fields of geology, environment, building and construction, medicine and health physics.
The science essay uses science to think about the human condition; it …
The science essay uses science to think about the human condition; it uses humanistic thinking to reflect on the possibilities and limits of science and technology. In this class we read and practice writing science essays of varied lengths and purposes. We will read a wide variety of science essays, ranging across disciplines, both to learn more about this genre and to inspire your own writing. This semester's reading centers on The Dark Side," with essays ranging from Alan Lightman's "Prisoner of the Wired World" through Robin Marantz Henig's cautionary account of nano-technology ("Our Silver-Coated Future") to David Quammen's investigation of diseases that jump from animals to humans ("Deadly Contact")."
Extensive reading of works by a few major poets. Emphasizes the evolution …
Extensive reading of works by a few major poets. Emphasizes the evolution of each poet's work and the questions of poetic influence and literary tradition. Instruction and practice in oral and written communication. Topic for Fall: Does Poetry Matter? Topic for Spring: Gender and Lyric Poetry.
This unit focuses on teaching students about the many aspects of biomedical …
This unit focuses on teaching students about the many aspects of biomedical engineering (BME). Students come to see that BME is a broad field that relies on concepts from many engineering disciplines. They also begin to understand some of the special considerations that must be made when dealing with the human body. Activities and class discussions encourage students to think as engineers to come up with their own solutions to some of medical challenges that have been solved throughout the history of BME. Class time iincludes brainstorming and presenting ideas to the class for discussion. Specific activities include examination of the material properties and functions of surgical instruments and prosthetics, a simulation of the training experience of a surgical resident, and an investigation of the properties of fluid flow in vascular tissue.
This collection uses primary sources to explore the polio epidemic and vaccine. …
This collection uses primary sources to explore the polio epidemic and vaccine. Digital Public Library of America Primary Source Sets are designed to help students develop their critical thinking skills and draw diverse material from libraries, archives, and museums across the United States. Each set includes an overview, ten to fifteen primary sources, links to related resources, and a teaching guide. These sets were created and reviewed by the teachers on the DPLA's Education Advisory Committee.
The emergence of Western science: the systematization of natural knowledge in the …
The emergence of Western science: the systematization of natural knowledge in the ancient world, the transmission of the classical legacy to the Latin West, and the revolt from classical thought during the scientific revolution. Examines scientific concepts in light of their cultural and historical contexts.
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