The principles and practice of tissue engineering (and regenerative medicine) are taught by faculty of the Harvard-MIT Division of Health Sciences and Technology (HST) and Tsinghua University, Beijing, China. The principles underlying strategies for employing selected cells, biomaterial scaffolds, soluble regulators or their genes, and mechanical loading and culture conditions, for the regeneration of tissues and organs in vitro and in vivo are addressed. Differentiated cell types and stem cells are compared and contrasted for this application, as are natural and synthetic scaffolds. Methodology for the preparation of cells and scaffolds in practice is described. The rationale for employing selected growth factors is covered and the techniques for incorporating their genes into the scaffolds are examined. Discussion also addresses the influence of environmental factors including mechanical loading and culture conditions (e.g., static versus dynamic). Methods for fabricating tissue-engineered products and devices for implantation are taught. Examples of tissue engineering-based procedures currently employed clinically are analyzed as case studies.

Principles of Continuum Applied Mathematics covers fundamental concepts in continuous applied mathematics, including applications from traffic flow, fluids, elasticity, granular flows, etc. The class also covers continuum limit; conservation laws, quasi-equilibrium; kinematic waves; characteristics, simple waves, shocks; diffusion (linear and nonlinear); numerical solution of wave equations; finite differences, consistency, stability; discrete and fast Fourier transforms; spectral methods; transforms and series (Fourier, Laplace). Additional topics may include sonic booms, Mach cone, caustics, lattices, dispersion, and group velocity.

This course introduces the design of feedback control systems as applied to a variety of air and spacecraft systems. Topics include the properties and advantages of feedback systems, time-domain and frequency-domain performance measures, stability and degree of stability, the Root locus method, Nyquist criterion, frequency-domain design, and state space methods.

This course surveys a variety of reasoning, optimization and decision making methodologies for creating highly autonomous systems and decision support aids. The focus is on principles, algorithms, and their application, taken from the disciplines of artificial intelligence and operations research. Reasoning paradigms include logic and deduction, heuristic and constraint-based search, model-based reasoning, planning and execution, and machine learning. Optimization paradigms include linear programming, integer programming, and dynamic programming. Decision-making paradigms include decision theoretic planning, and Markov decision processes.

This course provides an introduction to the chemistry of biological, inorganic, and organic molecules.ĺĘTheĺĘemphasis isĺĘon basic principles of atomic and molecular electronic structure, thermodynamics, acid-base and redox equilibria, chemical kinetics, and catalysis. In an effort to illuminate connections between chemistry and biology, a list of the biology-, medicine-, and MIT research-related examples used in 5.111 is provided in Biology-Related Examples. Acknowledgements Development and implementation of the biology-related materials in this course were funded through an HHMI Professors grant to Prof. Catherine L. Drennan.

Principles of Computer System Design: An Introduction is published in two parts. Part I, containing chapters 1-6, is a traditional printed textbook published by Morgan Kaufman, an imprint of Elsevier. Part II, containing chapters 7-11, is available here as an open educational resource. This textbook, an introduction to the principles and abstractions used in the design of computer systems, is an outgrowth of notes written for 6.033 Computer System Engineering over a period of 40-plus years. Individual chapters are also used in other EECS subjects. There is also a Web site for the current 6.033 class with a lecture schedule that includes daily Assignments and Labs, lecture notes, and lecture slides. The 6.033 class Web site also contains a thirteen-year archive of class Assignments and Labs, design projects, and quizzes. Technical Requirements: Special software is required to use some of the files in this resource: .key, .ppt, and .zip.

Deals with more advanced design theories and textual analysis. Emphasis on script analysis in general, as well as from a designer's perspective. Students also refine technical skills in rendering and presentation, historical research, and analysis. Class sessions include interaction with student/faculty directors and other staff designers. Goal is for students to approach text with a fresh vision and translate that vision into design for performance.

The course serves as an introduction to the theory and practice behind many of today's communications systems. 6.450 forms the first of a two-course sequence on digital communication. The second class, 6.451 Principles of Digital Communication II, is offered in the spring. Topics covered include: digital communications at the block diagram level, data compression, Lempel-Ziv algorithm, scalar and vector quantization, sampling and aliasing, the Nyquist criterion, PAM and QAM modulation, signal constellations, finite-energy waveform spaces, detection, and modeling and system design for wireless communication.

This class introduces students to the interdisciplinary nature of 21st-century engineering projects with three threads of learning: a technical toolkit, a social science toolkit, and a methodology for problem-based learning. Students encounter the social, political, economic, and technological challenges of engineering practice by participating in real engineering projects with faculty and industry; this semester's major project focuses on the engineering and economics of solar cells. Student teams will create prototypes and mixed media reports with exercises in project planning, analysis, design, optimization, demonstration, reporting and team building.

Covers current understanding of and modern approaches to human disease, emphasizing the molecular and cellular basis of both genetic disease and cancer. Specific topics include the genetics of simple and complex traits; Karyotypic analysis and positional cloning; genetic diagnosis; the roles of oncogenes and tumor suppressors in tumor initiation, progression and treatment; the interaction between genetics and environment; animal models of human disease; cancer; and conventional and gene therapy treatment strategies.

This course covers the principles of main group (s and p block) element chemistry with an emphasis on synthesis, structure, bonding, and reaction mechanisms.

This course is designed to introduce classic macroeconomic issues such as growth, inflation, unemployment, interest rates, exchange rates, technological progress, and budget deficits. The course will provide a unified framework to address these issues and to study the impact of different policies, such as monetary and fiscal policies, on the aggregate behavior of individuals. These analytical tools will be used to understand the recent experience of the United States and other countries and to address how current policy initiatives affect their macroeconomic performance.

Principles of Microeconomics is an introductory undergraduate course that teaches the fundamentals of microeconomics. This course introduces microeconomic concepts and analysis, supply and demand analysis, theories of the firm and individual behavior, competition and monopoly, and welfare economics. Students will also be introduced to the use of microeconomic applications to address problems in current economic policy throughout the semester.

This course presents principles of naval architecture, ship geometry, hydrostatics, calculation and drawing of curves of form, intact and damage stability, hull structure strength calculations and ship resistance. It introduces computer-aided naval ship design and analysis tools. Projects include analysis of ship lines drawings, calculation of ship hydrostatic characteristics, analysis of intact and damaged stability, ship model testing, and hull structure strength calculations.

This course introduces theoretical and practical principles of design of oceanographic sensor systems. Topics include: transducer characteristics for acoustic, current, temperature, pressure, electric, magnetic, gravity, salinity, velocity, heat flow, and optical devices; limitations on these devices imposed by ocean environments; signal conditioning and recording; noise, sensitivity, and sampling limitations; and standards. Lectures by experts cover the principles of state-of-the-art systems being used in physical oceanography, geophysics, submersibles, acoustics. For lab work, day cruises in local waters allow students to prepare, deploy and analyze observations from standard oceanographic instruments.

Studies the principles of deterministic optimal control. Variational calculus and Pontryagin's maximum principle. Applications of the theory, including optimal feedback control, time-optimal control, and others. Dynamic programming and numerical search algorithms introduced briefly.

An introduction to pharmacology. Topics include mechanisms of drug action, dose-response relations, pharmacokinetics, drug delivery systems, drug metabolism, toxicity of pharmacological agents, drug interactions, and substance abuse. Selected agents and classes of agents examined in detail.

Explores the interaction of radiation with matter at the microscopic level from both the theoretical and experimental viewpoints. Emphasis on radiation effects in biological systems. Topics include energy deposition by various types of radiation, including the creation and behavior of secondary radiations; the effects of radiation on cells and on DNA; and experimental techniques used to measure these radiation effects. Cavity theory, microdosimetry and methods used to simulate radiation track structure are reviewed. Examples of current literature used to relate theory, modeling, and experimental methods. Requires a term paper and presentation. The central theme of this course is the interaction of radiation with biological material. The course is intended to provide a broad understanding of how different types of radiation deposit energy, including the creation and behavior of secondary radiations; of how radiation affects cells and why the different types of radiation have very different biological effects. Topics will include: the effects of radiation on biological systems including DNA damage; in vitro cell survival models; and in vivo mammalian systems. The course covers radiation therapy, radiation syndromes in humans and carcinogenesis. Environmental radiation sources on earth and in space, and aspects of radiation protection are also discussed. Examples from the current literature will be used to supplement lecture material.

The aim of this course is to introduce the principles of the Global Positioning System and to demonstrate its application to various aspects of Earth Sciences. The specific content of the course depends each year on the interests of the students in the class. In some cases, the class interests are towards the geophysical applications of GPS and we concentrate on high precision (millimeter level) positioning on regional and global scales. In other cases, the interests have been more toward engineering applications of kinematic positioning with GPS in which case the concentration is on positioning with slightly less accuracy but being able to do so for a moving object. In all cases, we concentrate on the fundamental issues so that students should gain an understanding of the basic limitations of the system and how to extend its application to areas not yet fully explored.

This 6-unit subject gives students the opportunity to immerse themselves in the poetry of two living Nobel Laureates: the Caribbean poet, Derek Walcott, and the Northern-Irish poet, Seamus Heaney. We will begin and end the semester with their magnificent epic works: Heaney's translation of the Anglo-Saxon epic Beowulf, and Walcott's Omeros (a modern epic set in the West Indies). Between these major narrative poems, we will read a rich selection of their shorter poems, as well as some of their reflections in prose on what poetry does, on what other poets do, and what it means to write in English from the historical and political situation of Northern Ireland (for Heaney) or the Caribbean (for Walcott).