This is a peer-reviewed chapter in an open access book, Mineral Deficiencies. This chapter serves as an introduction to the emerging field of nutrigenomics (NG), a specialized branch of nutritional research which examines gene-diet interactions and its role in chronic disease. The chapter highlights the effects of specific food components on the genes which predispose individuals to chronic diseases such as: obesity, CVD, diabetes and cancer. The chapter does contain some grammatical and spelling errors, but the information contained is clear and relevant. It is a technical reading that is best suited to nurses, physicians, nutritionists, and other allied health professionals at both the undergraduate and graduate level.