In this course we will explore how altered metabolism drives cancer progression. Students will learn (1) how to read, discuss, and critically evaluate scientific findings in the primary research literature, (2) how scientists experimentally approach fundamental issues in biology and medicine, (3) how recent findings have challenged the traditional “textbook” understanding of metabolism and given us new insight into cancer, and (4) how a local pharmaceutical company is developing therapeutics to target cancer metabolism in an effort to revolutionize cancer therapy.

This course serves as an introduction to the structure and function of the nervous system. Emphasis is placed on the cellular properties of neurons and other excitable cells. Topics covered include the structure and biophysical properties of excitable cells, synaptic transmission, neurochemistry, neurodevelopment, and the integration of information in simple systems and the visual system.

Surveys the molecular and cellular mechanisms of neuronal communication. Covers ion channels in excitable membrane, synaptic transmission, and synaptic plasticity. Correlates the properties of ion channels and synaptic transmission with their physiological function such as learning and memory. Discusses the organizational principles for the formation of functional neural networks at synaptic and cellular levels.

Covers cells and tissues of the immune system, lymphocyte development, the structure and function of antigen receptors, the cell biology of antigen processing and presentation including molecular structure and assembly of MHC molecules, lymphocyte activation, the biology of cytokines, leukocyte-endothelial interactions, and the pathogenesis of immunologically mediated diseases. Consists of lectures and tutorials in which clinical cases are discussed with faculty tutors. Details of the case covering a number of immunological issues in the context of disease are posted on a student Web site.

This is a course for those who are interested in the challenge posed by massive and persistent world poverty, and are hopeful that economists might have something useful to say about this challenge. The questions we will take up include: Is extreme poverty a thing of the past? What is economic life like when living under a dollar per day? Why do some countries grow fast and others fall further behind? Does growth help the poor? Are famines unavoidable? How can we end child labor - or should we? How do we make schools work for poor citizens? How do we deal with the disease burden? Is micro finance invaluable or overrated? Without property rights, is life destined to be "nasty, brutish and short"? Has globalization been good to the poor? Should we leave economic development to the market? Should we leave economic development to non-governmental organizations (NGOs)? Does foreign aid help or hinder? Where is the best place to intervene?

Laboratory or field work in atmospheric science and oceanography. To be arranged with department faculty. Consult with department Education Office. This is an undergraduate introductory laboratory subject in ocean chemistry and measurement. There are three main elements to the course: oceanic chemical sampling and analysis, instrumentation development for the ocean environment, and the larger field of ocean science. This course is offered as part of the MIT/WHOI Joint Program in Oceanography/Applied Ocean Science and Engineering.

Introduces the design of chemical reactors via synthesis of chemical kinetics, transport phenomena, and mass and energy balances. Topics: reaction mechanisms and chemical/biochemical pathways; transition-state theory; batch, plug flow and well-stirred reactors; heterogeneous and enzymatic catalysis; heat and mass transport in reactors, including diffusion to and within catalyst particles and cells or immobilized enzymes.

For Institute students in all departments interested in the behavior of chemicals in the environment (see ESD listings for other subjects). Emphasis on man-made chemicals, their movement through water, air, soil, and their eventual fate. Physical transport, as well as chemical and biological sources and sinks, are discussed. Linkages to health effects, sources and control, and policy aspects.

This course addresses the challenges of defining a relationship between exposure to environmental chemicals and human disease. Course topics include epidemiological approaches to understanding disease causation; biostatistical methods; evaluation of human exposure to chemicals, and their internal distribution, metabolism, reactions with cellular components, and biological effects; and qualitative and quantitative health risk assessment methods used in the U.S. as bases for regulatory decision-making. Throughout the term, students consider case studies of local and national interest.

This course is an intensive introduction to the techniques of experimental chemistry and gives first year students an opportunity to learn and master the basic chemistry lab techniques for carrying out experiments. Students who successfully complete the course and obtain a "Competent Chemist" (CC) or "Expert Experimentalist" (EE) rating are likely to secure opportunities for research work in a chemistry lab at MIT. Acknowledgements The laboratory manual and materials for this course were prepared by Dr. Katherine J. Franz and Dr. Kevin M. Shea with the assistance of Professors Rick L. Danheiser and Timothy M. Swager. Materials have been revised by Dr. J. Haseltine, Dr. Kevin M. Shea, Dr. Sarah A. Tabacco, Dr. Kimberly L. Berkowski, Anne M. (Gorham) Rachupka, and Dr. John J. Dolhun. WARNING NOTICE The experiments described in these materials are potentially hazardous and require a high level of safety training, special facilities and equipment, and supervision by appropriate individuals. You bear the sole responsibility, liability, and risk for the implementation of such safety procedures and measures. MIT shall have no responsibility, liability, or risk for the content or implementation of any of the material presented. Legal Notice 

This seminar will focus on three sports: swimming, cycling and running. There will be two components to the seminar: classroom sessions and a "laboratory" in the form of a structured training program. The classroom component will introduce the students to the chemistry of their own biological system. With swimming, running and cycling as sample sports, students are encouraged to apply their knowledge to complete a triathlon shortly after the term.

This course studies the transformation of childhood and youth since the 18th century in France, as well as the development of sentimentality within the family in a francophone context. Students will examine the personification of children, both as a source of inspiration for artistic creation and a political ideal aimed at protecting future generations, and consider various representations of childhood and youth in literature (e.g., Pagnol, Proust, Sarraute, Lave, Morgievre), movies (e.g., Truffaut), and songs (e.g., Brel, Barbara). This course is taught entirely in French.

This lecture course provides students with a comprehensive introduction to the international relations of the People's Republic of China. China's foreign relations during the Cold War as well as contemporary diplomatic, security and economic issues will be examined to identify and explain China's foreign policy goals and their implementation since 1949. Throughout, this course will investigate the sources of conflict and cooperation in China's behavior, assessing competing explanations for key events and policies. Readings will be drawn from political science, history, and international relations theory.

China's rise as a great power raises important questions about how that power might be used in its relations with other states. Nowhere are such questions more salient than in the future trajectory of China's conflict behavior, including its approach to deterrence, crisis management and the use of force. To explore these important questions in China's international relations, this seminar examines the evolution of Chinese strategic thought, in primary sources as well as its reflection in the interactions among Chinese states and between China and other states.

This course forms the intermediate level of what constitutes a four-term foundation in Mandarin. Upon completion of Chinese III and IV, students should be able to speak Chinese with fluency on everyday topics, reach a literacy level of 700 characters (approximately 2000 common words written in both traditional and simplified characters), read materials in simple standard written Chinese, and produce both orally and in writing short compositions on everyday topics. Throughout the course we will address issues of how cultural differences inform and are informed by different linguistic contexts and practices.

This subject is the second semester of four that forms an introduction to modern standard Chinese, commonly called Mandarin. The emphasis is on further developing students' abilities to participate in simple, practical conversations on everyday topics as well as enhancing their abilities on reading and writing. The relationship between Chinese language and culture and the sociolinguistically appropriate use of language will be stressed throughout. A typical class includes performance of memorized basic conversations, drills, questions and discussion, and various types of communicative exercises. At the end of this course, students are expected to develop an understanding of the language learning process so that they will be able to continue studying effectively on their own.

This course, along with 21G.107 / 157 Chinese I (Streamlined) offered in the previous fall, form the elementary level of the streamlined sequence, which is intended for students who, when they began the sequence at beginning level, had basic conversational skills (gained, typically, from growing up in a Chinese speaking environment), but lacked a corresponding level of literacy. The focus of the course is on standard usage, on reading in both traditional and simplified characters, and on writing. The course is conducted entirely in Chinese.

This subject is the first semester of two that form an introduction to modern standard Chinese, commonly called Mandarin. Though not everyone taking this course will be an absolute beginner, the course presupposes no prior background in the language. The purpose of this course is to develop: Basic conversational abilities (pronunciation, fundamental grammatical patterns, common vocabulary, and standard usage); Basic reading and writing skills (in both the traditional character set and the simplified); and An understanding of the language learning process so that you are able to continue studying effectively on your own.The main text is Wheatley, J. K. Learning Chinese: A Foundation Course in Mandarin. Part I. (unpublished, but available online). (Part II of the book forms the basis of 21F.102 / 152, which is also published on OpenCourseWare.)

This course, along with 21G.108 / 158 offered in the spring, form the elementary level of the streamlined sequence, which is for students who have some basic conversational skills gained, typically, from growing up in a Chinese speaking environment, but lack a corresponding level of literacy. The focus of the course is on learning standard everyday usage, on reading in both full and simplified characters, and on writing. This course, along with 21G.108 / 158 offered in the spring, are conducted entirely in Chinese.

This is the second semester of the intermediate level sequence intended for students whose conversational ability exceeds their reading and writing skills. Focus is on reading and writing, as well as broadening conversational skills and control of standard pronunciation, for students with background in conversational Chinese. Lab work is required. On completing this course, students should be able to speak the language with standard pronunciation, to converse with some fluency on everyday topics, as well as on some specialized topics, to read edited, as well as authentic texts, in simplified or traditional characters with suitable fluency, and to be able to write composition on certain topics. The class consists of a combination of practice, reading, discussion, dictation, composition and feedback, net exploration via the web, and presentation. This course is conducted in Mandarin.