Provides graduate students and fellows with techniques that enhance both validity and responsible conduct in scientific practice. Topics include study design, laboratory practice, treatment of data, human and animal research, intellectual property, preparation of proposals, research papers, posters, and oral presentations. Also discussed are mentoring relationships and career options. Aspects of responsible research conduct are integrated as appropriate to the specific topic under discussion. Subject satisfies the training grant requirements of the NIH for education in the responsible conduct of research. This course is designed to provide graduate students and postdoctoral associates with techniques that enhance both validity and responsible conduct in scientific practice. Lectures present practical steps for developing skills in scientific research and are combined with discussion of cases. The course covers study design, preparation of proposals and manuscripts, peer review, authorship, use of humans and non-human animals in research, allegations of misconduct, and intellectual property. Also discussed are mentoring relationships and career options. Aspects of responsible research conduct are integrated into lectures and case discussion as appropriate to the specific topic. This course also satisfies the training grant requirements of the NIH for education in the responsible conduct of research.

Students are introduced to the unit challenge discovering a new way to assess a person's risk of breast cancer. Solving this challenge requires knowledge of refraction and the properties of light. After being introduced to the challenge question, students generate ideas related to solving the challenge, and then read a short online article on optical biosensors that guides their research towards solving the problem.

Through four lessons and three hands-on activities, students learn the concepts of refraction and interference in order to solve an engineering challenge: "In 2013, actress Angelina Jolie underwent a double mastectomy, not because she had been diagnosed with breast cancer, but merely to lower her cancer risk. But what if she never inherited the gene(s) that are linked to breast cancer and endured surgery unnecessarily? Can we create a new method of assessing people's genetic risks of breast cancer that is both efficient and cost-effective?" While pursuing a solution to this challenge, students learn about some high-tech materials and delve into the properties of light, including the equations of refraction (index of refraction, Snell's law). Students ultimately propose a method to detect cancer-causing genes by applying the refraction of light in a porous film in the form of an optical biosensor. Investigating this challenge question through this unit is designed for an honors or AP level physics class, although it could be modified for conceptual physics.

Welcome to the online coursebook for our Theories and Biological Basis of Addiction course. The material is designed to be read interactively or after downloading; while the embedded interactive exercises require internet connectivity, each can also be downloaded for offline work. These exercises are presented to help you test and apply what you are reading, challenge yourself, prepare for quizzes, and have a little fun along the way. The list of key terms at the end explains text highlighted in bold italics throughout the book—in the interactive mode you can click on a highlighted word to jump to its explanation in the key terms section. Use the back arrow to return to where you were reading.

Students learn about glaucoma its causes, how it affects individuals and how biomedical engineers can identify factors that trigger or cause this eye disease, specifically the increase of pressure in the eye. Students also learn how RFID technologies transfer energy through waves and how engineers apply their scientific understanding of waves, energy and sensors to develop devices that measure the pressure in the eyes of people with glaucoma. Students conclude by sketching their own designs for a pressure-measuring eye device, preparing them to conduct the associated activity in which they revise, prototype and evaluate their device designs made tangible with a 3D printer.

Tumor pathophysiology plays a central role in the growth, metastasis, detection, and treatment of solid tumors. Principles of transport phenomena are applied to develop a quantitative understanding of angiogenesis (formation of new blood vessels), blood flow and microcirculation, metabolism and microenvironment, transport and binding of small and large molecules, movement of cancer and immune cells, metastatic process, radiotherapy, chemotherapy, immunotherapy, hyperthermia, and photodynamic therapy of solid tumors.

Diagnostic Imaging principles and concepts are augmented by the presentation of imaging for common clinical conditions. Guiding principles related to minimizing radiation exposure and requesting the most appropriate imaging examination is addressed. Static images are enhanced by the ability to access images stored and displayed on an Html-5 compatible, Dicom image viewer that simulates a simple Picture Archive and Communication system (PACS). Users can also access other imaging from the Dicom viewer (ODIN), beyond the basic curriculum provided, to further advance their experience with viewing diagnostic imaging pathologies.This book is also available in three other digital formats: ePUB (for Nook, iBooks, Kobo etc.), PDF (regular print), PDF (large print).

This is a peer-reviewed chapter in an open access book, ADHD. This chapter provides an overview of complementary and alternative medicine (CAM) and its relevance in psychiatric practice for the use of natural health products in the treatment of ADHD. Several botanical agents, nutritional interventions and supplements are reviewed. Results of the reviewed human clinical trials are presented in a concise tabular format. Methods, results, proposed mechanism of action, safety and efficacy are all addressed. The chapter is accurate, relevant, and clear. It is extensively referenced and is still relevant today even though more up-to-date literature reviews are available. It is a technical reading that is best suited to nurses, physicians, nutritionists, mental health workers and other allied health professionals at both the undergraduate and graduate level.

This unit on nanoparticles engages students with a hypothetical Grand Challenge Question that asks about the skin cancer risk for someone living in Australia, given the local UV index and the condition of the region's ozone layer. The question asks how nanoparticles might be used to help detect, treat and protect people from skin cancer. Through three lessons, students learn about the science of electromagnetic radiation and energy waves, human skin and its response to ultraviolet radiation, and the state of medical nanotechnology related to skin cancer. Through three hands-on activities, students perform flame tests to become familiar with the transfer of energy in quantum form, design and conduct their own quality-control experiments to test sun protection factors (SPFs), and write nanotechnology grant proposals.

Students are presented with a biomedical engineering challenge: Breast cancer is the second-leading cause of cancer-related death among women and the American Cancer Society says mammography is the best early-detection tool available. Despite this, many women choose not to have them; of all American women at or over age 40, only 54.9% have had a mammogram within the past year. One reason women skip annual mammograms is pain, with 90% reporting discomfort. Is there a way to detect the presence of tumors that is not as painful as mammography but more reliable and quantifiable than breast self-exams or clinical breast exams? This three lesson/three activity unit is designed for first-year accelerated or AP physics classes. It provide hands-on activities to teach the concepts of stress, strain and Hooke's law, which students apply to solve the challenge problem.

The purpose of this textbook is to provide an introductory, yet comprehensive, source of information on epidemiology for veterinary students, researchers, and practitioners. There has not been a textbook that presents analytic epidemiology as a science, basic to veterinary medicine's efforts in health management (herd health) as well as in clinical medicine.

Veterinary Histology is a microscopic anatomy textbook focused on domestic species, including the dog, cat, cattle, horses, swine, and camelids. This digital textbook provides comprehensive, system-specific text as well as high-resolution, annotated images along with chapter-specific glossary of terms and learning objectives.

Students learn how viruses invade host cells and hijack the hosts' cell-reproduction mechanisms in order to make new viruses, which can in turn attack additional host cells. Students also learn how the immune system responds to a viral invasion, eventually defeating the viruses -- if all goes well. Finally, they consider the special case of HIV, in which the virus' host cell is a key component of the immune system itself, severely crippling it and ultimately leading to AIDS. The associated activity, Tracking a Virus, sets the stage for this lesson with a dramatic simulation that allows students to see for themselves how quickly a virus can spread through a population, and then challenges students to determine who the initial bearers of the virus were.

The purpose of this textbook is to help learners develop best practices in vital sign measurement. Using a multi-media approach, it will provide opportunities to read about, observe, practice, and test vital sign measurement.

In this service-learning engineering project, students follow the steps of the engineering design process to design a hearing testing device. More specifically, they design a prototype machine that can be used to test the peripheral vision of partially-blind, pre-verbal children. Students learn about the basics of vision and vision loss. They also learn how a peripheral vision tester for adults works (by testing the static peripheral vision in the four quadrants of the visual field with four controllable lights in specific locations). Then they modify the idea of the adult peripheral vision tester to make it usable for testing young children. The class designs and builds one complete prototype, working in sub-groups of four or five students each to build sub-components of the project design.

Students are presented with the unit's grand challenge problem: You are the lead engineer for a biomaterials company that has a cardiovascular systems client who wants you to develop a model that can be used to test the properties of heart valves without using real specimens. How might you go about accomplishing this task? What information do you need to create an accurate model? How could your materials be tested? Students brainstorm as a class, then learn some basic information relevant to the problem (by reading the transcript of an interview with a biomedical engineer), and then learn more specific information on how heart tissues work their structure and composition (lecture information presented by the teacher). This prepares them for the associated activity, during which students cement their understanding of the heart and its function by dissecting sheep hearts to explore heart anatomy.

Students are introduced to the concepts of the challenge question. First independently, and then in small groups, they generate ideas for solving the grand challenge introduced in the associated lesson: Your grandmother has a fractured hip and a BMD of -3.3. What medical diagnosis explains her condition? What are some possible causes? What are preventative measures for other family members? Students complete a worksheet that contains the pertinent questions, as well as develop additional questions of their own, all with the focus on determining what additional background knowledge they need to research. Finally, as a class, students compile their ideas, resulting in a visual as a learning supplement.

According to the United States Agency for International Development, 20 million people in developing countries require wheelchairs, and the United Nations Development Programme estimates below 1% of their need is being met in Africa by local production. Wheelchair Design in Developing Countries (WDDC) gives students the chance to better the lives of others by improving wheelchairs and tricycles made in the developing world. Lectures will focus on understanding local factors, such as operating environments, social stigmas against the disabled, and manufacturing constraints, and then applying sound scientific/engineering knowledge to develop appropriate technical solutions. Multidisciplinary student teams will conduct term-long projects on topics such as hardware design, manufacturing optimization, biomechanics modeling, and business plan development. Theory will further be connected to real-world implementation during guest lectures by MIT faculty, Third-World community partners, and U.S. wheelchair organizations. This class is made possible by an MIT Alumni Sponsored Funding Opportunities grant with additional support from the National Collegiate Inventors and Innovators Alliance, the MIT Public Service Center, and the MIT Edgerton Center; special thanks to CustomInk.com.

Students further their understanding of the engineering design process while combining mechanical engineering and bioengineering to create assistive devices. During this extended activity (seven class periods), students are given a fictional client statement and required to follow the steps of the engineering design process (EDP) to design a new wristwatch face for a visually impaired student at their school. Student groups share their designs with the class through design presentations. A successful design meets all of the student-generated design requirements, including the development of a new method of representing time that does not require the sense of sight. Through this activity, students design, construct and iterate classroom prototypes of their watch designs.